The San Francisco 49ers (2-3) and Seattle Seahawks (3-2) will meet on Thursday Night Football. Both teams lost as favorites in Week 5 and are looking to bounce back. The Arizona Cardinals topped the 49ers, 24-23, as San Francisco was held scoreless in the second half. Meanwhile, the Seahawks fell short to the New York Giants at home, 29-20. 

Kickoff at Lumen Field is set for 8:15 p.m. ET. San Francisco is a 3.5-point favorite in the latest 49ers vs. Seahawks odds, while the over/under for total points scored is 49.5. The 49ers are -187 money-line favorites (risk $187 to win $100), while the Seahawks are +157 underdogs.

Before making any 49ers vs. Seahawks picks or predictions of your own, you NEED to see which side SportsLine NFL expert Micah Roberts is on. 

Micah Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Roberts has a strong read on the pulse of the 49ers. In fact, he is an amazing 23-5 (+1750) on his last 28 picks in games involving San Francisco. Anybody following is way up.

Now, Roberts has locked in another confident against-the-spread pick for 49ers vs. Seahawks.

We can tell you he's leaning Over the point total, but he also knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins 49ers vs. Seahawks on Thursday Night Football, and what x-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the 49ers-Seahawks spread hits HARD, all from the expert who is an AMAZING 23-5 on picks involving the 49ers!